Science, Culture, and Innovation for a Sustainable Future. Introductory considerations to the project.

Aprile 19, 2024

Sustainability and health are deeply intertwined, shaping each other in numerous ways. Sustainability entails meeting the needs of present generations without jeopardizing the ability of future ones to do the same. Health encompasses the holistic well-being of individuals, encompassing physical, mental, and social dimensions.

An approach to health that prioritizes sustainability involves promoting healthy lifestyles and ensuring access to high-quality medical care and services. Conversely, investing in health can bolster sustainability efforts. By preventing diseases and promoting health, we can mitigate long-term healthcare costs, thereby enhancing economic sustainability.

Considering the topic of the PRAESIIDIUM project, type 2 diabetes mellitus, is a global health concern with significant financial implications. Direct global health expenditure on diabetes was estimated approximately USD 760 billion in 2019, and it is projected to escalate to USD 825 billion by 2030 and USD 845 billion by 2045[1]. This immense economic burden highlights the urgency of proactive measures to address the underlying causes and risk factors associated with the disease.

In our project, we are dedicated to identifying individuals at risk of developing type 2 diabetes through the analysis of biomarkers in those with prediabetes. Prediabetes, often a precursor to full-blown diabetes, presents a crucial window of opportunity for intervention and prevention. By leveraging biomarkers and advanced diagnostic techniques, we aim to detect subtle physiological changes indicative of impending diabetes onset.

Early detection is key to implementing timely interventions that can halt or even reverse the progression of the disease. Through targeted lifestyle modifications, personalized dietary interventions, and pharmacological strategies, we strive to empower individuals to take control of their health and mitigate their risk of developing type 2 diabetes.

Beyond the individual level, our efforts have broader implications for healthcare systems and society at large. By reducing the incidence of type 2 diabetes and its associated complications, we anticipate a substantial reduction in healthcare costs and an improvement in overall public health outcomes. Moreover, by promoting preventive healthcare practices and fostering a culture of wellness, we can cultivate a more resilient and sustainable healthcare ecosystem for future generations.

In conclusion, the intersection of sustainability and health presents a fertile ground for innovative approaches to addressing pressing global health challenges such as type 2 diabetes mellitus. By adopting a holistic perspective that considers both the immediate health needs of individuals and the long-term sustainability of healthcare systems, we can forge a path toward a healthier, more equitable future for all.


By Natalia Rosso, Pablo Giraudi, Prof Claudio Tiribelli and the Fondazione Fegato Onlus (FIF) team.

[1] Williams R, Karuranga S, Malanda B, Saeedi P, Basit A, Besançon S, Bommer C, Esteghamati A, Ogurtsova K, Zhang P, Colagiuri S. Global and regional estimates and projections of diabetes-related health expenditure: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2020 Apr;162:108072. doi: 10.1016/j.diabres.2020.108072.